Key result
Cashew nut testa total extract and saponin-rich fraction ameliorated blood glucose, lipid profiles, and pancreatic IRS-1 expression, and restored damaged pancreas and islets in hyperglycemic mice.
Why the study?
Does cashew nut testa extract and fraction improve blood glucose, lipid profile, and pancreatic histology in STZ/HFD-induced hyperglycemic mice?
Population
Hyperglycemic mice induced with a high-fat diet for 4 weeks and injected with streptozotocin for 2 weeks
Comparison
Cashew nut testa total extract or saponin-rich… vs Pioglitazone (PG) and untreated hyperglycemic mice
Design
Preclinical
Follow-up
3 weeks
Authors
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Should not change practice; leaves open cashew nut testa extracts for hypothesis-generating diabetes research.
Does cashew nut testa extract and fraction improve blood glucose, lipid profile, and pancreatic histology in STZ/HFD-induced hyperglycemic mice?
Cashew nut testa extract and saponin-rich fraction ameliorate hyperglycemia, improve lipid profiles, and restore pancreatic histology in a mouse model of type 2 diabetes.
Van et al. (2023) studied Type 2 diabetes mellitus / Hyperglycemia. Cashew nut testa total extract (TE) and saponin-rich fraction (SRF) vs. Pioglitazone and untreated hyperglycemic mice was evaluated on Body mass, blood glucose level, blood glucose tolerance, lipid profile, pancreatic histology, and IRS-1 expression. Cashew nut testa total extract and saponin-rich fraction ameliorated blood glucose, lipid profiles, and pancreatic IRS-1 expression, and restored damaged pancreas and islets in hyperglycemic mice.
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