Key result
Angiotensin II elicited receptor crosstalk in single catecholaminergic neurons, characterized by sequential AT1-mediated decreases and AT2-mediated increases in IK.
Population
Catecholaminergic neurons
Design
Preclinical
Authors
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Hypothesis-generating for neuronal Ang II signaling in autonomic control; leaves open translation to human cardiovascular physiology or therapy.
This study demonstrates for the first time the existence of functional crosstalk between Ang II receptor subtypes (AT1 and AT2) in single catecholaminergic neurons.
Craig H. Gelband (1997) studied this question. Angiotensin II was evaluated on Electrophysiological responses (IK). Angiotensin II elicited receptor crosstalk in single catecholaminergic neurons, characterized by sequential AT1-mediated decreases and AT2-mediated increases in IK.
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