Key result
Children with Familial Mediterranean Fever had a significantly higher QTc value compared to healthy controls (412.15 vs 393.58, p=0.005), although the values remained within normal limits.
Why the study?
Patients with inflammatory diseases such as FMF are at increased risk of cardiovascular complications due to rhythm disorders, but the role of QT and JT dispersion as arrhythmogenic markers in children with FMF is not well defined.
Case-Control (n=79)
No
Absolute Event Rate: 412.15% vs 393.58%
p-value: p=0.005
Familial Mediterranean Fever (FMF) is an autoimmune, autosomal recessive inherited disorder, and characterized by recurrent episodes of peritonitis, plöritis and arthritis. Patients with inflammatory disease are at increased risk of cardiovascular complications due to rhythm disorders. QT and JT dispersions are simple and non-invasive arrhythmogenic markers and can be used to assess the homogeneity of cardiac repolarization.
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Fidancı et al. (2013) conducted a case-control in Familial Mediterranean Fever (FMF) (n=79). Familial Mediterranean Fever (FMF) vs. Healthy children was evaluated on QTc value (p=0.005). Children with Familial Mediterranean Fever had a significantly higher QTc value compared to healthy controls (412.15 vs 393.58, p=0.005), although the values remained within normal limits.
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