Cortical and subcortical gray matter structural alterations in normoglycemic obese and type 2 diabetes patients: relationship with adiposity, glucose, and insulin

Figures

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  Fig. 1. Clusters of lower cortical gray matter surface indices overlaid on a standard brain for right cortical thickness, left panel, and left surface area, right panel. Red-Yellow indicate the positive group effect, whereas blue-light blue indicates a negative effect

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  Fig. 2. Scatter plot of the correlations between clusters of altered cortical structure and medical and anthropometric variables. Green circles depict the healthy lean controls, blue triangles the normoglycemic obese, and red squares the obese T2DM patients. The black regression line shows the correlation for the whole group. The colored regression lines depict the correlation for either the normoglycemic obese (blue) or obese T2DM (red) participants. The correlation with sex is presented as mean with standard deviation and represents men and women irrespective or group allocation

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  Fig. 3. Scatter plot of the correlations between altered subcortical structures and medical and anthropometric variables. Green circles depict the healthy lean controls, blue triangles the normoglycemic obese, and red squares the obese T2DM patients. The black regression line shows the correlation for the whole group. The colored regression lines depict the correlation for either the normoglycemic obese (blue) or obese T2DM (red) participants. The correlation with sex is presented as mean with standard deviation and represents men and women irrespective or group allocation

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  Fig. 4. Schematic representation of the clusters where insulin, was significantly negatively related to either, surface area, thickness, or volume in all participants. Blue-light blue indicates a negative correlation, whereas red-yellow indicates a positive correlation

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  Fig. 5. Scatter plot of the correlations between clusters that showed a vertex-wise correlation with insulin. Green circles depict the healthy lean controls, blue triangles the normoglycemic obese, and red squares the obese T2DM patients. The black regression line shows the correlation for the whole group. The colored regression lines depict the correlation for either the normoglycemic obese (blue) or obese T2DM (red) participants