Key result
Exercise-induced LVEF drop in aortic regurgitation correlates strongly with persistent postoperative dysfunction.
Why the study?
The potential irreversibility of isometric exercise-induced left ventricular dysfunction in aortic regurgitation and its impact on timing of valve replacement was unclear.
Does isometric exercise testing predict the reversibility of left ventricular dysfunction after aortic valve replacement in patients with chronic aortic regurgitation?
Comparison
Preoperative vs postoperative handgrip exercise tests and control group
Design
Observational study with cardiac catheterization exercise testing
Authors
Loading...
Isometric exercise-induced LV dysfunction in AR may signal irreversible changes; leaves open whether preoperative testing should guide AVR timing.
Observational (n=26)
Does isometric exercise testing predict the reversibility of left ventricular dysfunction after aortic valve replacement in patients with chronic aortic regurgitation?
Effect estimate: r = 0.85
p-value: p=<0.001
Isometric exercise-induced left ventricular dysfunction in aortic regurgitation is partly irreversible, suggesting that valve replacement should be performed before stress-induced dysfunction develops.
Huikuri et al. (1983) conducted an observational in Chronic aortic regurgitation (n=26). Handgrip exercise test vs. Normal subjects was evaluated on Change in ejection fraction during exercise (r = 0.85, p=<0.001). Preoperative ejection fraction decreases during handgrip exercise in aortic regurgitation correlated with postoperative exercise responses (r = 0.85, P<0.001), indicating partial irreversibility.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: