Key result
Modified Caprini score plus hemoglobin and D-dimer accurately predicts postoperative VTE with an AUC of ~0.82.
Why the study?
Postoperative venous thromboembolism is a significant cause of morbidity and mortality in lung cancer patients, but risk identification remains limited.
Does the modified Caprini risk assessment model combined with hemoglobin and D-dimer levels improve the prediction of postoperative VTE in patients with resectable lung cancer?
Cohort
No
Does the modified Caprini risk assessment model combined with hemoglobin and D-dimer levels improve the prediction of postoperative VTE in patients with resectable lung cancer?
The modified Caprini risk assessment model combined with hemoglobin and D-dimer levels provides good diagnostic performance for predicting postoperative VTE in lung cancer patients.
Answers are grounded in this paper and cite their sources.
May enhance postoperative VTE risk stratification in lung cancer; hypothesis-generating and requires prospective validation before practice change.
Background: Postoperative venous thromboembolism (VTE) is a well-documented cause of morbidity and mortality in lung cancer patients. However, risk identification remains limited. In this study, we sought to analyze the risk factors for VTE and verify the predictive value of the modified Caprini risk assessment model (RAM). Methods: This prospective single-center study included patients with resectable lung cancer who underwent resection between October 2019 and March 2021. The incidence of VTE was estimated. Logistic regression was used to analyze the risk factors for VTE. Receiver operating characteristic (ROC) curve analysis was performed to test the ability of the modified Caprini RAM to predict VTE. Results: The VTE incidence was 10.5%. Several variables, including age, D-dimer, hemoglobin (Hb), bleeding, and patient confinement to bed were significantly associated with VTE after surgery. The difference between the VTE and non-VTE groups in the high-risk levels was statistically significant (P<0.001), while the low and moderate risk levels showed no significant difference. The combined use of the modified Caprini score and the Hb and D-dimer levels showed an area under the curve (AUC) was 0.822 [95% confidence interval (CI): 0.760-0.855. P<0.001]. Conclusions: The risk-stratification approach of the modified Caprini RAM is not particularly valid after lung resection in our population. The use of the modified Caprini RAM combined with Hb and D-dimer levels shows a good diagnostic performance for VTE prediction in patients with lung cancer undergoing resection.
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Ding et al. (2023) conducted a cohort in Lung cancer. Modified Caprini risk assessment model combined with Hb and D-dimer levels was evaluated on Postoperative venous thromboembolism (VTE) (AUC 0.822, 95% CI 0.760-0.855, p=<0.001). The modified Caprini risk assessment model combined with hemoglobin and D-dimer levels accurately predicted postoperative VTE in lung cancer patients (AUC 0.822; 95% CI 0.760-0.855; P<0.001).
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