The N-acylsulfathiazole deriviatives 2, 3 and 4, the polymeric N-acylsulfathiazole 6 and the phenolic sulfathiazole analogue 7 were prepared and were found to promote crystallization of form I sulfathiazole from water with inhibition of forms II, III and IV; suggesting that the mode of action of the additives may involve other factors in addition to compatibility with the hydrogen-bonding structure of the various forms.
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Kelleher et al. (2006) studied this question.
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