Key result
Sodium nitroprusside safely induces target hypotension in pediatric spinal surgery.
Why the study?
The hypotensive response to sodium nitroprusside in children undergoing spinal surgery for kyphoscoliosis was investigated to determine effective dosing and safety.
Does sodium nitroprusside infusion achieve satisfactory hypotension in children undergoing spinal surgery for kyphoscoliosis?
Population
30 children aged 5-15 years undergoing spinal surgery for kyphoscoliosis
Comparison
Sodium nitroprusside infusion at 10 microg/kg/minute
Design
Observational study
Authors
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May support controlled hypotension in pediatric spinal surgery; hypothesis-generating and requires randomized confirmation before practice change.
Does sodium nitroprusside infusion achieve satisfactory hypotension in children undergoing spinal surgery for kyphoscoliosis?
Sodium nitroprusside infused at 10 mcg/kg/min safely achieves satisfactory controlled hypotension in children undergoing spinal surgery.
Bennett et al. (1977) studied Kyphoscoliosis undergoing spinal surgery (n=30). Sodium nitroprusside was evaluated on Hypotensive response (systolic arterial pressure 70-80 mmHg). Sodium nitroprusside infused at 10 microng/kg/minute achieved satisfactory hypotension (70-80 mmHg systolic) in children undergoing spinal surgery without serious side effects.
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