Synthesis of the mirror image of β‐D‐riboguanosine 5′‐phosphate a substrate to study chiral selection in non‐enzymatic RNA synthesis

Abstract β‐L‐Riboguanosine 5′‐phosphate (5′pLG) was prepared by transglycosidation of properly protected L‐ribose and guanine derivatives followed by phosphorylation and removal of all protecting groups. Experiments indicated that 5′pDG was selected from a mixture of L and D isomers in template directed oligomerization of RNA.