Key result
Edoxaban resolves internal jugular vein thrombosis and preserves free flap survival post-reconstruction.
Why the study?
Internal jugular vein thrombosis after head and neck reconstruction can cause flap congestion and necrosis, requiring early diagnosis and treatment.
Does edoxaban resolve internal jugular vein thrombosis and prevent flap necrosis in patients after head and neck reconstruction?
Case Report (n=1)
No
Does edoxaban resolve internal jugular vein thrombosis and prevent flap necrosis in patients after head and neck reconstruction?
Edoxaban was successfully used as a single-drug approach to treat internal jugular vein thrombosis and salvage a free flap after head and neck reconstruction.
May support edoxaban for IJV thrombosis after free flap reconstruction; single case leaves open need for prospective validation.
Internal jugular vein thrombosis (IJVT) is a complication of neck dissection. After head and neck reconstruction, flap congestion due to IJVT may lead to flap necrosis, and early diagnosis and treatment should be considered. We experienced a case of disappearance of IJVT in which edoxaban was administered after free-flap reconstruction, and the entire flap survived. Edoxaban has few bleeding complications and was useful as a single drug approach for IJVT after head and neck reconstruction.
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Sasaki et al. (2020) conducted a case report in Internal jugular vein thrombosis after head and neck reconstruction (n=1). Edoxaban was evaluated on Thrombus resolution and flap survival. Administration of edoxaban successfully resolved internal jugular vein thrombosis and ensured complete survival of the free flap following head and neck reconstruction.
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