Key result
Edoxaban resolves malignancy-associated upper-extremity DVT and thrombus burden without bleeding complications.
Why the study?
Management of thrombosis in the internal jugular and upper limb veins associated with Trousseau syndrome and gastric cancer is not well characterized.
Case Report (n=1)
No
Edoxaban successfully treated upper extremity and jugular deep vein thrombosis in a patient with Trousseau syndrome secondary to gastric cancer without bleeding complications.
May indicate occult malignancy despite initial negative workup; leaves open optimal surveillance duration for unprovoked upper-extremity thrombosis.
A 45-year-old man complained of swelling of the left side of his neck and left upper limb. Ultrasonography and enhanced computed tomography (CT) revealed thrombosis of the left internal jugular, subclavian, and brachiocephalic vein. Based on various examinations, the patient was diagnosed with idiopathic venous thrombosis early in his clinical course. There were no findings to suggest malignancy or abnormal coagulability. However, two months after the start of treatment, the patient was diagnosed with gastric cancer. Despite the presence of Trousseau syndrome, treatment with edoxaban (an oral anticoagulant), reduced the swelling dramatically without any bleeding complications.
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Toratani et al. (2017) conducted a case report in Upper-extremity deep vein thrombosis and Trousseau syndrome (n=1). Edoxaban was evaluated on Clinical improvement and thrombus size reduction. Edoxaban treatment dramatically reduced swelling and thrombus size without bleeding complications in a patient with malignancy-related upper-extremity deep vein thrombosis.
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