Key result
Hematologic malignancies linked to ~91% higher in-hospital AMI mortality compared to no cancer.
Why the study?
In-hospital outcomes of acute myocardial infarction in patients with hematological malignancies and their subtypes were not well characterized.
Observational (n=162,953,092)
Yes
Absolute Event Rate: 16.8% vs 8.8%
p-value: p=<0.0001
Acute myocardial infarction in patients with hematological malignancies is associated with significantly higher in-hospital mortality, length of stay, and costs compared to those with non-hematological malignancies.
May warrant closer monitoring in AMI patients with hematological malignancies; leaves open whether targeted strategies improve outcomes.
Introduction The purpose of our study is to determine in-hospital outcomes of acute myocardial infarction in patients with hematological malignancies and their subtypes. Method Patient data were obtained from the nationwide inpatient sample (NIS) database between the years 2009-2014. Patients with hematological cancer subtypes and acute MI (non-ST segment elevation myocardial infarction and ST-segment elevation myocardial infarction (NSTEMI/STEMI) were identified using validated international classification of diseases (ninth revision) and clinical modification (ICD-9-CM) codes. Statistical analysis using the chi-square test was performed to determine the hospital outcomes of acute MI in patients with hematological cancers and subtypes. Results The prevalence of acute myocardial infarction was 2.4% in patients with hematological neoplasms (N=3,027,800). Amongst the subtypes of blood cancers, the highest prevalence of acute MI was seen in lymphocytic leukemia (2.9%). The mortality of MI in patients with hematological malignancies was 16.8% vs 8.8% in patients with non-hematological malignancies, in-hospital costs were $25469 ± 36763 vs. $20534 ± 24767, and length of in-hospital stay was 8.3 ± 10 vs 6.3 ± 7.8 days. Amongst the hematological cancer subtypes, the highest mortality of acute MI was found in myeloid leukemia (23%) followed by multiple myeloma (MM) (17.9%), lymphocytic leukemia (15.9%), and lymphoma (14.4%). The length of stay and hospitalization cost was highest for myeloid leukemia, followed by MM, lymphocytic leukemia, and lymphoma. Conclusion This study showed that acute MI in patients with hematological malignancies has higher in-hospital mortality, length of stay, and cost. Amongst the blood neoplasm subtypes the highest mortality, length of hospital stay, and hospitalization cost were found in myeloid leukemia.
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Khan et al. (2022) conducted an observational in Acute myocardial infarction (n=162,953,092). Hematological malignancies vs. No cancer was evaluated on In-hospital mortality of acute myocardial infarction (p=<0.0001). Acute myocardial infarction in patients with hematological malignancies was associated with significantly higher in-hospital mortality compared to patients without cancer (16.8% vs 8.8%, p<0.0001).
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