Animal study demonstrates thyroid follicular necrosis and biochemical alterations in rats exposed to B[a]P and BDE-47, highlighting pollutant toxicity on endocrine tissue.
High Resolution Image Download MS PowerPoint Slide Benzo[ a ]pyrene (B[ a ]P) and 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) are widespread environmental pollutants and can destroy thyroid function. We assessed the biochemical changes in the thyroid tissue of rats exposed to B[ a ]P and BDE-47 using attenuated total reflection Fourier-transform infrared spectroscopy combined with support vector machine(SVM). After B[ a ]P and BDE-47 treatment in rats, the structure of thyroid follicles was destroyed and epithelial cells were necrotic, indicating that B[ a ]P and BDE-47 may lead to changes of the thyroid morphology of the rats. These damages are mainly related to C═O stretch vibrations of lipids (1743 cm –1 ), as well as the secondary structure of proteins [amide I (1645 cm –1 ) and amide II (1550 cm –1 )], and carbohydrates [C–OH (1138 cm –1 ), C–O (1106 cm –1, 1049 cm –1, 991 cm –1 ), C–C (1106 cm –1 ) stretching] and collagen (phosphodiester stretching at 922 cm –1 ) vibration modes. When SVM was used for classification, there was a substantial separation between the control and the exposure groups (accuracy = 96%; sensitivity = 98%; specificity = 87%), and there was also a major separation between the exposed groups (accuracy = 93%; sensitivity = 94%; and specificity = 92%).
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Lao et al. (2024) studied this question.
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