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We have developed carbon nanotube-based dual-mode biosensors with a metal semiconductor field effect transistor structure on a quartz substrate. DNA hybridization occurring on the Au top gate can be detected by simultaneously measuring the change in the electrical conductance and the surface plasmon resonance (SPR). Since electrical and SPR measurements offer high sensitivity and reliability, respectively, this dual-mode biosensor is expected to provide both of these features.
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Oh et al. (2010) studied this question.
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