Key result
EZSCAN-based formula achieves ~77% accuracy for detecting impaired glucose tolerance and type 2 diabetes.
Why the study?
Clinical diagnosis of diabetes mellitus is time-consuming and invasive, motivating investigation of a noninvasive diagnostic formula using EZSCAN and anthropometric data in the Chinese population.
Does a diagnostic formula based on EZSCAN autonomic testing and anthropometric data accurately detect IGT and T2DM in a Chinese population?
Cross-Sectional (n=1,547)
No
Does a diagnostic formula based on EZSCAN autonomic testing and anthropometric data accurately detect IGT and T2DM in a Chinese population?
A diagnostic formula combining EZSCAN autonomic testing and anthropometric data provides a convenient and sensitive non-invasive screening option for diabetes and impaired glucose tolerance.
Should not yet change screening practice; leaves open whether EZSCAN formulas improve diabetes detection efficiency.
Clinical diagnosis of diabetes mellitus (DM) is time-consuming and invasive. This study aimed to investigate the efficacy and accuracy of EZSCAN in detecting impaired glucose tolerance (IGT) and diabetes mellitus (DM) in Chinese population, and explore a diagnosis formula based on an autonomic test using EZSCAN measurement and anthropometric data. Eligible subjects (n = 1547) had the following data collected: those of anthropometric and EZSCAN measurements and biochemical tests including FPG, OGTT, HbA1c, and serum lipid tests. The support vector machine (SVM) algorithm method was used to derive a diagnostic formula. In this study, 452 and 263 subjects were diagnosed with T2DM and IGT, respectively, while 832 had normal glucose tolerance (NGT). The sensitivity rates for the formula were 77.2% for T2DM and 80.4% for IGT. The diagnostic formula was found to correlate strongly with EZSCAN values. The diagnostic formula based on autonomic test and anthropometric data appears to be a convenient and accurate routine screening option in the Chinese population.
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Zhao et al. (2020) conducted a cross-sectional in Impaired glucose tolerance and Type 2 Diabetes Mellitus (n=1,547). Diagnostic formula (EZSCAN, age, and diastolic blood pressure) vs. Standard biochemical tests (OGTT, FPG, HbA1c) was evaluated on Diagnostic accuracy of the SVM-derived formula for T2DM and IGT. A diagnostic formula based on EZSCAN autonomic testing and anthropometric data achieved 77% diagnostic accuracy, with 77.2% sensitivity for type 2 diabetes and 80.4% for impaired glucose tolerance.
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