Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3

This is the authors' abstract. We don't add key points for this paper.

Voltage-gated potassium channels (K V ) play vital roles in electrically excitable and non-excitable cells. They usually open with membrane depolarization and allow the flow of K + ions. Ion flow through these channels is curtailed by time-dependent entry into non-conducting inactivated states 1 . Inactivation allows channels to close even in the face of continued stimulation and can occur rapidly (in ms, N-type) or slowly (in s, C-type). This tight governance of ion flow by inactivation is essential for the timing and control functions of K V channels.