Key result
Priming with an adenovirus vector and boosting with vaccinia virus vectors expressing a single CD8+-T-cell epitope and RANK ligand efficiently protected mice from lethal Trypanosoma cruzi infection.
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No immediate clinical implications; leaves open translation of vector-based epitope vaccines to human Chagas disease.
Miyahira et al. (2005) studied Trypanosoma cruzi infection. Priming with adenovirus vector expressing ANYNFTLV and boosting with vaccinia virus vectors expressing ANYNFTLV and RANK ligand was evaluated on Protection from subsequent challenge with lethal doses of T. cruzi. Priming with an adenovirus vector and boosting with vaccinia virus vectors expressing a single CD8+-T-cell epitope and RANK ligand efficiently protected mice from lethal Trypanosoma cruzi infection.
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