Key result
Impaired endothelial insulin transport contributes to insulin resistance, though human muscle mechanisms remain poorly understood.
Why the study?
The regulation of muscle transendothelial insulin transfer, especially in humans, is poorly understood despite evidence supporting endothelial insulin transport's role in insulin resistance.
Highlights the emerging understanding of the vascular endothelium's role in transendothelial insulin transport and its contribution to insulin resistance.
Endothelial control of insulin transit to muscle may contribute to resistance; leaves open vascular-targeted therapies in diabetes.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Barrett et al. (2012) conducted a review in Insulin resistance. Accumulating evidence supports a contribution of endothelial insulin transport to insulin resistance, though the regulation of muscle transendothelial insulin transfer in humans is poorly understood.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: