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WITHIN the past decade, studies by molecular geneticists on the composition and organization of immunoglobulin (Ig)-coding genes at the DNA level have vastly increased our understanding of the genetic mechanisms responsible for generating antibody diversity and for linking Ig synthesis to cellular differentiation. This new information, which has far-reaching biological and clinical implications, has come from research on B cell-related lymphocytic and plasma cell tumors and on their monoclonal Ig products—Bence Jones proteins, myeloma proteins, and Waldenstrom macroglobulins.
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Alan Solomon (1986) studied this question.
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