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August 1, 1969Biochemical JournalOpen Access

The reversibility of the Δ8-cholestenol–Δ7-cholestenol isomerase reaction in cholesterol biosynthesis

D C Wilton Anver D. Rahimtula M. Akhtar

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Abstract

The incubation of Delta(7)-cholestenol with a 10000g supernatant or 105000g microsomes in the presence of tritiated water is studied. The reisolated Delta(7)-cholestenol contained up to 0.67g.atom of tritium/mole. This result can best be explained by assuming the reversibility of the reaction Delta(8)-cholestenol right harpoon over left harpoon Delta(7)-cholestenol.

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Cite This Study

Wilton et al. (1969) studied this question.

synapsesocial.com/papers/6ab5d8ea9f5e94797d862fb1 https://doi.org/10.1042/bj1140071

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