Key result
Bariatric surgery significantly decreased menstrual irregularity (RR -0.83; 95% CI -1.00 to -0.65; P<0.00001) and BMI (MD -13.64; 95% CI -16.29 to -10.99; P<0.00001) in patients with obesity and PCOS.
Why the study?
Does bariatric surgery improve clinical and biochemical markers in patients with obesity and PCOS?
Meta-Analysis
Does bariatric surgery improve clinical and biochemical markers in patients with obesity and PCOS?
Relative Risk: -0.83 (95% CI -1–-0.65)
p-value: p=< 0.00001
Bariatric surgery significantly improves both metabolic (BMI) and reproductive/hormonal abnormalities in patients with obesity and PCOS.
Bariatric surgery improves menstrual regularity, BMI, and hyperandrogenism in obese PCOS; extends meta-analytic support but leaves open need for RCTs.
Polycystic ovary syndrome (PCOS) is a multifactorial disease, which is closely related to obesity. This study evaluated the efficacy of bariatric surgery on obesity complicated with PCOS through meta-analysis. PubMed, Cochrane, EMbase, and WOS databases were searched from 2012 to November 2022. Studies on the efficacy of bariatric surgery in the treatment of obesity combined with PCOS were included. Outcome indicators included menstrual abnormalities, BMI, free testosterone, hypertrichosis, and ovarian volume. Methodological quality of the included studies was evaluated, and statistical analysis was performed using RevMan 5.3 software. Finally, 9 studies were included, and the results of meta-analysis were as follows: After weight loss surgery, menstrual irregularity decreased (RR = -0.83, 95%CI:-1.00∼-0.65, P < 0.00001), and BMI decreased significantly (MD = -13.64, 95%CI:-16.29∼-10.99, P < 0.00001). Free testosterone levels decreased (MD = -22.70, 95 % CI: -36.07 ∼ -9.34, P < 0.00001), the incidence of hypertrichosis decreased (RR = 0.63, 95%CI: 0.45-0.88, p = 0.007 < 0.01), and the ovarian volume decreased (MD = -3.09, 5%CI: -5.76 ∼ -0.42, P < 0.00001).
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Chen et al. (2024) conducted a meta-analysis in obesity complicated with polycystic ovary syndrome. bariatric surgery was evaluated on menstrual irregularity (RR -0.83, 95% CI -1.00 to -0.65, p=< 0.00001). Bariatric surgery significantly decreased menstrual irregularity (RR -0.83; 95% CI -1.00 to -0.65; P<0.00001) and BMI (MD -13.64; 95% CI -16.29 to -10.99; P<0.00001) in patients with obesity and PCOS.
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