Key result
Complex karyotypes in intravascular large B-cell lymphoma showed no significant difference in progression-free survival (p=0.92) or overall survival (p=0.61) compared to normal karyotypes.
Why the study?
What are the karyotypic abnormalities and heterogeneities in intravascular lymphoma, and do they affect survival?
Cohort (n=13)
No
What are the karyotypic abnormalities and heterogeneities in intravascular lymphoma, and do they affect survival?
p-value: p=0.92 for PFS, p=0.61 for OS
Approximately half of intravascular large B-cell lymphoma cases exhibit highly complex and heterogeneous karyotypes, though this does not appear to significantly impact survival outcomes.
Small IVL cohort data warrant cautious interpretation; leaves open cytogenetic prognostic value pending larger studies.
AIMS: To characterise the karyotypic abnormalities and heterogeneities in intravascular lymphoma (IVL). METHODS: G-banded karyotyping was performed on biopsy specimens from a single-centre IVL cohort comprising intravascular large B-cell lymphoma (IVLBCL, n=12) and NK/T-cell lymphoma (IVNKTCL, n=1). RESULTS: Five IVLBCL cases and one IVNKTCL case (total 46%) were found to have normal karyotypes, and the cytogenetic abnormalities observed in the other seven IVLBCL cases (54%) were investigated further. These seven karyotypes were uniformly complex with an average of 13 aberrations. The seven cases all had abnormalities involving chromosome 6, with 57% involving structural abnormalities at 6q13, and chromosome 8, with 43% involving abnormalities at 8p11.2. In addition, 71% had aberrations at 19q13. On average, 4.4 chromosomal gains and losses were detected per case. Cytogenetic heterogeneities were observed in six cases (86%) and tetraploidy in three cases (43%). There was no significant difference in progression-free survival (p=0.92) and overall survival (p=0.61) between the IVLBCL cases with complex and normal karyotypes. CONCLUSION: Approximately half of IVLBCL cases had a highly heterogeneous pattern of karyotypes with different clonal numerical and structural chromosome aberrations.
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Fujikura et al. (2020) conducted a cohort in Intravascular lymphoma (n=13). Complex karyotype vs. Normal karyotype was evaluated on Progression-free survival and overall survival (p=p=0.92 for PFS, p=0.61 for OS). Complex karyotypes in intravascular large B-cell lymphoma showed no significant difference in progression-free survival (p=0.92) or overall survival (p=0.61) compared to normal karyotypes.
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