Lack of association between genetic variations in CYP3A5 and blood pressure or hypertension risk in the UK biobank

Figures

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  FIGURE 1. Estimated effects (β coefficients) of CYP3A5 variant alleles on blood pressure. β coefficients were generated using linear regression models and are displayed relative to the functional CYP3A5*1 allele. The squares represent the β coefficient/effect of the variants on the outcomes with the size of the squares reflecting the precision. The lines represent the confidence intervals of each association. BP, blood pressure; DBP, diastolic blood pressure; MAP, mean arterial blood pressure; SBP, systolic blood pressure.

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  FIGURE 2. Estimated effects (ORs) of CYP3A5 variant alleles on HTN risk. ORs were generated using logistic regression models and are displayed relative to the functional CYP3A5*1 allele. The squares represent the ORs/effect of the variants on the outcomes with the size of the squares reflecting the precision. The lines represent the confidence intervals of each association. HTN, hypertension; OR, odds ratio.

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  FIGURE 3. Estimated effects (β coefficients) of genotype-predicted CYP3A5 activity on blood pressure in the primary analysis in the overall population and in the different racial subgroups. β coefficients were generated using linear regression models and are displayed relative to the functional CYP3A5*1 allele. The squares represent the β coefficient/effect of the variants on the outcomes with the size of the squares reflecting the precision. The lines represent the confidence intervals of each association. BP, blood pressure; DBP, diastolic blood pressure; MAP, mean arterial blood pressure; SBP, systolic blood pressure.

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  FIGURE 4. Estimated effects (ORs) of genotype predicted CYP3A5 activity on HTN risk in the primary analysis in the overall population and in the different racial subgroups. ORs were generated using logistic regression. The squares represent the ORs/effect of the variants on the outcomes with the size of the squares reflecting the precision. The lines represent the confidence intervals of each association. HTN, hypertension; OR, odds ratio.