Key result
Power and sample size calculations require equal partnership between investigators and statisticians.
Why the study?
Sample size justification is required for all clinical studies, but many biomedical and clinical researchers find power and sample size analysis difficult to understand.
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Design
Discussion note on power and sample size calculations
Clinicians and statisticians must partner early on power calculations; leaves open standardized workflows for routine adoption.
Sample size justification is required for all clinical studies. However, to many biomedical and clinical researchers, power and sample size analysis seems like a magic trick of statisticians. In this note, we discuss power and sample size calculations and show that biomedical and clinical investigators play a significant role in making such analyses possible and meaningful. Thus, power analysis is really an interactive process and scientific researchers and statisticians are equal partners in the research enterprise.
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Zheng et al. (2017) studied this question. Power and sample size calculations are an interactive process requiring equal partnership between biomedical investigators and statisticians.
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