Triazoles and Other N‐Containing Metabolites from the Marine‐Derived Endophytic Fungus Penicillium chrysogenum EN‐118

Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2‐(4‐hydroxyphenyl)acetamides, 5 and 6, and two known N‐(4‐hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN‐118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR‐spectroscopic analysis, and that of compound 1 was confirmed by X‐ray crystallographic analysis of its p‐bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A‐549, and HeLa cell lines.