Key result
Medical management fails to halt idiopathic calciphylaxis progression, necessitating major limb amputation.
Why the study?
Idiopathic calciphylaxis cases without identifiable causes and effective treatments are rare and challenging to manage.
Case Report (n=1)
Idiopathic calciphylaxis can be refractory to medical therapies including LMWH, hyperbaric oxygenation, and etidronate, ultimately requiring major limb amputation.
May warrant amputation consideration in refractory calciphylaxis; leaves open effective therapies.
A 68-year-old woman presented with a painful necrotic ulcer on her right calf and necrotic breakdown of a left below-knee amputation stump as a result of calciphylaxis. No cause could be identified and corrected. Treatment comprised wound care, substituting low molecular weight heparin for warfarin, hyperbaric oxygenation and etidronate disodium, none of which were helpful and major limb amputations were considered the best option for this patient.
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Banky et al. (2002) conducted a case report in Idiopathic calciphylaxis (n=1). Wound care, low molecular weight heparin, hyperbaric oxygenation, and etidronate disodium was evaluated on Clinical improvement. Medical management including wound care, low molecular weight heparin, hyperbaric oxygenation, and etidronate disodium was ineffective for idiopathic calciphylaxis, necessitating major limb amputation.
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