The role of adenosine 3':5'-cyclic monophosphate (cAMP) in the regulation of neuroblast mitosis and survival by vasoactive intestinal peptide (VIP) was examined. VIP increased the cAMP content of cultured rat sympathetic neuroblasts. Further, cAMP stimulated DNA synthesis and survival in neuroblast cultures, replicating the effects of VIP. Thus, the VIP-cAMP signaling pathway may be involved in the regulation of neuronal development.
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Pincus et al. (1990) studied this question.
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