Key result
Altered fluid mechanics and lipid-derived mediators drive chronic arterial inflammation underlying atheroma formation.
Why the study?
Atheroma formation is suggested to be a chronic inflammatory response influenced by fluid mechanics and lipid-derived inflammatory mediators at specific arterial sites.
This review highlights the interplay between local fluid mechanics and lipid-derived inflammatory mediators in driving the chronic inflammatory response underlying atheroma formation.
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Provides mechanistic framework for atheroma; leaves open targeted clinical validation in prospective studies.
Henry et al. (1993) conducted a review in Atheroma formation. Fluid mechanics and lipid-derived inflammatory mediators was evaluated. Atheroma formation is proposed to be a chronic inflammatory response driven by altered fluid mechanics at arterial flow dividers and the accumulation of lipid-derived inflammatory mediators.
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