Key result
Annexin A2 is upregulated ~4-fold in HCC compared to non-tumorous liver tissue.
Why the study?
The role of Annexin A2 in various liver diseases including hepatocellular carcinoma remains obscure and requires further investigation.
Observational (n=78)
No
Effect estimate: Ratio 4.2 ± 1.3
p-value: p=<0.01
Overexpression and tyrosine phosphorylation of ANXA2 are associated with the malignant transformation process leading to hepatocellular carcinoma.
ANXA2 overexpression and phosphorylation in HCC tissues may signal progression; leaves open biomarker or therapeutic roles pending higher-level evidence.
Annexins (ANXs) constitute a family of Ca2+-dependent membrane-binding proteins; at least 20 of them have been described to date. Among these, Annexin A2 (ANXA2) has been revealed as a multi-functional protein in vitro. Its actual role in vivo, however, requires further investigation. We already reported that ANX-I (ANXA1) was up-regulated in hepatocellular carcinoma (HCC). The role of ANXA2 in various liver diseases including HCC remains obscure. In the present study, the protein and mRNA levels of ANXA2, as well as its localization, were determined for the normal human liver, chronic hepatitis liver, and non-tumorous and tumorous portions of HCC tissues. ANXA2 was rarely detected in either normal or chronic hepatitis liver tissues, whereas it was overexpressed at both the transcriptional and translational levels in tumorous and non-tumorous regions of HCC. In addition, in many cases, more ANXA2 was expressed in the tumorous portion than in the non-tumorous portion of HCC. The expression of ANXA2 was mainly localized in cancer cells, especially in poorly differentiated HCC. Furthermore, ANXA2 was tyrosine-phosphorylated in HCC. These data suggest that overexpression and tyrosine phosphorylation of ANXA2 play important roles in the malignant transformation process leading to HCC and are related to the histological grade of HCC.
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Masaki Masaki (1992) conducted an observational in Hepatocellular carcinoma (n=78). Hepatocellular carcinoma (tumor tissue) vs. Non-tumorous liver tissue, chronic hepatitis, and normal liver was evaluated on Densitometric ratio of ANXA2 protein expression in tumorous versus non-tumorous tissues (Ratio 4.2 ± 1.3, p=<0.01). Annexin A2 expression was significantly upregulated in hepatocellular carcinoma compared to non-tumorous tissues (densitometric ratio 4.2, p<0.01) and was tyrosine-phosphorylated.
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