Key result
Capsaicin oleoresin treatment, alone or combined with amlodipine besylate, resulted in a non-significant trend towards decreased systolic blood pressure in spontaneously hypertensive rats compared to controls (p=0.086).
Why the study?
The effects of oral capsaicin oleoresin on arterial blood pressure and related hormonal and mineral parameters in spontaneously hypertensive rats were not fully understood.
Does capsaicin oleoresin alone or in combination with irbesartan or amlodipine besylate reduce blood pressure in spontaneously hypertensive rats?
RCT (n=40)
Randomized
No
Does capsaicin oleoresin alone or in combination with irbesartan or amlodipine besylate reduce blood pressure in spontaneously hypertensive rats?
Oral capsaicin oleoresin showed a non-significant trend toward reducing systolic blood pressure in spontaneously hypertensive rats, potentially mediated through alterations in aldosterone and arteriolar vascular tone.
Answers are grounded in this paper and cite their sources.
Non-significant trend in hypertensive rats does not support clinical use; leaves open further translational research.
The effects of oral intake of capsaicin oleoresin (CO) on arterial blood pressure was examined in male spontaneously hypertensive (SHR) rats. Animals were randomized into control (C), capsaicin oleoresin (CO), capsaicin oleoresin-irbesartan (COI) and capsaicin oleoresin-amlodipine besylate (COAB) fed groups. The experimental groups received 50 mg of Capsaicin Oleoresin only, CO with 25 mg of Irbesartan, and CO with 2.5 mg of Amlodipine per kilogram of body weight every other day for 4 weeks. Blood pressure was measured weekly by tail-cuff for 4 weeks. Biological samples were obtained at baseline, day 18, and day 34 (terminal) for aldosterone, arginine vasopressin (AVP), renin, 6-Keto-PGF-1α, Prostaglandin E2, catecholamines, adrenocorticotropic hormone (ACTH) levels, and serum minerals. Statistical significance was set at p≤0.05. The results trended towards decreasing (p=0.190) systolic blood pressure (SBP) in the COAB and CO compared to the COI and control groups. However, significance among group differences were observed for urine aldosterone and AVP, and serum sodium, calcium, magnesium, potassium, and catecholamine (p≤0.05), but not for ACTH, renin, and 6-Keto-PGF-1α levels. Capsaicin treatment was non-significantly associated with decreased SBP in SHR. These findings suggested that the effects of Capsaicin on SPB may involve aldosterone and arteriolar vascular tone.
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Oyonumo et al. (2016) conducted an RCT in Hypertension (n=40). Capsaicin oleoresin alone or with irbesartan or amlodipine besylate vs. Placebo (corn oil) was evaluated on Change in systolic blood pressure (mmHg) (p=0.086). Capsaicin oleoresin treatment, alone or combined with amlodipine besylate, resulted in a non-significant trend towards decreased systolic blood pressure in spontaneously hypertensive rats compared to controls (p=0.086).
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