Synthesis of Paclitaxel‐Conjugated β‐Cyclodextrin Polyrotaxane and Its Antitumor Activity

Cap it all: A β-cyclodextrin polyrotaxane was synthesized by using poly(propylene glycol) as the axle and β-cyclodextrin as the end cap. An antitumor agent, paclitaxel, was conjugated to it. The drug-conjugated polyrotaxane penetrates deep into tumors, impedes tumor growth, and prolongs the life of tumor-bearing mice better than Taxol.