Key result
Triple saphenous vein CABG achieves successful outcomes in a child with familial hypercholesterolemia and ACS.
Why the study?
Familial hypercholesterolemia is frequently associated with premature coronary artery disease and aortic valve involvement, and surgical treatment carries high risk.
Case Report (n=1)
This case demonstrates the feasibility of multi-vessel coronary artery bypass grafting in a pediatric patient with severe familial hypercholesterolemia and premature coronary artery disease following previous valvular surgery.
Familial hypercholesterolemia (FH) is a dominantly inherited disorder caused by mutation at the locus for the low-density lipoprotein (LDL) receptor and is frequently associated with premature coronary artery disease and aortic valve involvement. The surgical treatment of these complications is accompanied by a high degree of risk, even in skillful hands. An intensive cholesterol-lowering therapy and LDL aphaeresis in association with surgery may be useful. The case of a 12-year-old girl, with a medical history of familial hypercholesterolemia is reported here, operated two years previously for valvular aortic stenosis; Ross intervention was done. She was readmitted for acute coronary syndrome. Three coronary artery bypass grafting was performed with saphenous veins with positive results.
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Mleyhi et al. (2014) conducted a case report in Familial hypercholesterolemia and acute coronary syndrome (n=1). Three coronary artery bypass grafting with saphenous veins was evaluated. Three coronary artery bypass grafting with saphenous veins was successfully performed with positive results in a 12-year-old girl with familial hypercholesterolemia and acute coronary syndrome.
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