Key result
Ibuprofen resolves HIV-TB IRIS pericarditis and effusion without interrupting HAART or TB therapy.
Why the study?
Pericarditis and pericardial effusion are rare manifestations of immune reconstitution inflammatory syndrome in HIV and tuberculosis co-infected patients after starting HAART.
Case Report (n=1)
Ibuprofen can successfully treat rare pericarditis and pericardial effusion manifestations of IRIS in HIV-TB co-infected patients without requiring interruption of HAART or antituberculous therapy.
May support ibuprofen for IRIS pericarditis without interrupting therapy; hypothesis-generating case report requiring prospective validation.
Immune reconstitution inflammatory syndrome (IRIS) affects 30-43% of HIV and tuberculosis (TB) co-infected patients after starting highly active antiretroviral therapy (HAART). Pericarditis and pericardial effusion are rare manifestations of IRIS. We report a case of HIV-TB related IRIS that developed pericardial involvement. This complication resolved after treatment with ibuprofen. Antituberculous treatment and HAART were not interrupted.
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Rapose et al. (2007) conducted a case report in HIV-TB related immune reconstitution inflammatory syndrome (IRIS) with pericarditis and pericardial effusion (n=1). Ibuprofen was evaluated on Resolution of pericardial involvement. Treatment with ibuprofen successfully resolved pericarditis and pericardial effusion in a patient with HIV-TB related immune reconstitution inflammatory syndrome without interrupting HAART or TB therapy.
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