Key result
Frequent migraine attacks show no association with coronary vasospasm compared to controls.
Why the study?
Previous reports suggested an association between coronary vasospasm and migraine, hypothesizing both as manifestations of a generalized vasospastic disorder.
Are frequent migraine attacks associated with coronary vasospasm compared to tension headaches or healthy individuals?
Case-Control (n=131)
Are frequent migraine attacks associated with coronary vasospasm compared to tension headaches or healthy individuals?
Absolute Event Rate: 0% vs 0%
Frequent migraine attacks are not associated with asymptomatic coronary vasospasm on 24-hour ambulatory ECG monitoring, challenging the hypothesis of a generalized vasospastic disorder.
Does not support routine vasospasm testing in frequent migraine; leaves open links in other vascular phenotypes or triggers.
Previous reports have found an association between coronary vasospasm and migraine. It has been speculated that migraine and variant angina might be manifestations of a generalized vasospastic disorder. To investigate this hypothesis, 74 patients with frequent attacks of migraine were studied using 24-h continuous ambulatory electrocardiography to identify the presence of coronary vasospasm. Control groups consisted of 19 patients with tension headaches, and 38 healthy individuals. All subjects were free of heart disease. One patient in the migraine group and one patient in the control group had symptomless episodes of ST-segment depression not indicative of coronary vasospasm. Our data do not support the hypothesis that migraine and variant angina are components of a generalized vasospastic disorder.
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Pliml et al. (1991) conducted a case-control in Migraine (n=131). Frequent attacks of migraine vs. Tension headaches or healthy individuals was evaluated on Presence of coronary vasospasm. Frequent migraine attacks were not associated with coronary vasospasm, as 0% of patients in both the migraine (n=74) and control (n=57) groups exhibited evidence of vasospasm.
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