Lethal Midline Granuloma-Stewart Nasal Nk/T-Cell Lymphoma-0ur Experience

Lethal midline granuloma or Stewart granuloma now recognized as a Naso facial NK/T-cell lymphoma is a rare clinical entity characterized by destruction and mutilation of the naso facial area.It has an unknown etiology, often affect face, nose, para-nasal sinuses, palate, oral cavity and surrounding structures.Because clinical manifestations are often variable and non specific, and the majority of the clinicians are not aware of such a disease this diagnosis is not simple, plus most of the patient are diagnose and treat wrong by a number of doctor loosing time.Plus till the correct diagnosis.Wait for the results of biopsy, IHC, is a long way which lead to a delay in proper treatment the purpose of our article is to present 2 cases of lymphoma TK/NK with in a period of 15 years between them with the difference in possibilities of diagnosis, treatment, etiology, prognosis.Every case was a real challenge I can say a real battle to establish the final diagnosis and to collaborate with someone with experience in the treatment at this horrible disease.Because is very rare (my professor never encounter a patient with destructive midline granuloma in 40 years of work), a lot, s of doctors with different specialities ask for my opinion, because of my "large experience".These require not only clinical feeling but a lot of informations, which means intense study.