Key result
Knitted polycaprolactone valvular scaffolds show higher leakage at ~39% compared to stentless porcine valves.
Why the study?
State-of-the-art tissue engineered heart valves lack sufficient strength to withstand aortic blood pressure levels, necessitating development of stronger scaffolds.
Population
Knitted polycaprolactone scaffolds with fibrin gel (n=3 leakage, n=1 durability)
Comparison
Knitted scaffolds without cells vs stentless porcine valves
Design
Preclinical mechanical and biocompatibility testing
Authors
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Durability supports scaffold refinement; leaves open whether leakage can be reduced for in vivo testing.
Absolute Event Rate: 39% vs 8%
A novel polycaprolactone and fibrin scaffold for aortic valve tissue engineering demonstrates excellent durability and biocompatibility, though it currently exhibits higher leakage than porcine valves.
Lieshout et al. (2006) studied Tissue engineered heart valves. Knitted, fibrin-covered polycaprolactone scaffold vs. Stentless porcine valves was evaluated on Leakage. A knitted, fibrin-covered polycaprolactone valvular scaffold demonstrated proper opening and coaptation but had higher leakage (39%) compared to stentless porcine valves (8%).
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