Key result
Metabolic syndrome is linked to ~38% higher rate of poor coronary collaterals in obese angina.
Why the study?
The influence of metabolic syndrome on the development of coronary collaterals among obese patients with stable coronary artery disease was investigated.
Does metabolic syndrome reduce the development of coronary collaterals in obese patients with stable coronary artery disease?
Observational (n=104)
Does metabolic syndrome reduce the development of coronary collaterals in obese patients with stable coronary artery disease?
Absolute Event Rate: 82.3% vs 59.5%
p-value: p=0.019
Metabolic syndrome is independently associated with poorer development of coronary collaterals in obese patients with stable coronary artery disease.
May identify modifiable target in obese stable angina; hypothesis-generating and requires prospective validation before practice change.
Obesity is a growing pandemic. Among obese patients with significant coronary artery stenosis, development of coronary collaterals was investigated. Consecutive 104 obese patients with stable angina pectoris were enrolled. Coronary collaterals were assessed according to the Cohen and Rentrop grading system and classified into 2 as those with poor collaterals (grade 0-1, Group 1) and those with good collaterals (grade 2-3, Group 2). Group 1 had higher body mass index, shorter duration of angina pectoris than Group 2. Poor collaterals were present in 82.3% and 59.5% of patients with and without (P = .019) metabolic syndrome, respectively. Metabolic syndrome score (sum of each component) was found to be negatively correlated with Rentrop score (r = -691; P < .001). After controlling for symptom duration and body mass index, metabolic syndrome kept independent association with poor collaterals among obese patients (P = .043, B = 1.8). Metabolic syndrome appears to influence the development of coronary collaterals among obese patients with stable coronary artery disease.
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Hatice Ilgen Sasmaz (2008) conducted an observational in Obese patients with stable angina pectoris and significant coronary artery stenosis (n=104). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Poor coronary collaterals (Cohen and Rentrop grade 0-1) (p=0.019). Metabolic syndrome was associated with a higher prevalence of poor coronary collaterals compared to those without the syndrome (82.3% vs 59.5%, P=0.019) in obese patients with stable angina.
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