Key result
Alternative splicing of the P/Q-type channel at an EF-hand-like domain and the C terminus acts as a molecular switch controlling Ca2+-dependent facilitation among three distinct modes.
Population
Recombinant P/Q-type (Ca(V)2.1) channels and human brain tissue
Design
Preclinical
Authors
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Splicing-tuned CDF may refine neuronal signaling models; leaves open extension to cardiovascular channelopathies.
Alternative splicing of the P/Q-type calcium channel acts as a molecular switch controlling calcium/calmodulin-dependent facilitation, with region- and development-specific expression in the human brain.
Chaudhuri et al. (2004) studied this question. Alternative splicing of P/Q-type channel (CaV2.1) exon 37 and 47 vs. Different splice variants (EFa vs EFb, long vs short C-terminus) was evaluated on Ca2+-dependent facilitation (CDF) and inactivation (CDI). Alternative splicing of the P/Q-type channel at an EF-hand-like domain and the C terminus acts as a molecular switch controlling Ca2+-dependent facilitation among three distinct modes.
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