Key result
In children with MIS-C, the presence of rash was associated with higher serum probrain natriuretic peptide concentrations compared to those without rash.
Why the study?
The study aimed to investigate the management and cardiac involvement indicators in children diagnosed with multisystem inflammatory syndrome associated with COVID-19.
Do clinical symptoms such as rash and gastrointestinal dysfunction indicate cardiac involvement in children with MIS-C?
Observational (n=34)
No
Do clinical symptoms such as rash and gastrointestinal dysfunction indicate cardiac involvement in children with MIS-C?
In children with MIS-C, the presence of rash and sonographic visualization of ileitis are associated with elevated cardiac biomarkers, suggesting they may serve as clinical signs for cardiac involvement.
Answers are grounded in this paper and cite their sources.
Retrospective MIS-C data from 34 children may inform local protocols; leaves open need for prospective validation before broader adoption.
Objective This study aims to investigate the management of children diagnosed with “multisystem inflammatory syndrome” (MIS-C) potentially associated with coronavirus disease 2019 (COVID-19) at a tertiary health center. Methods This is a retrospective review of 34 children who were diagnosed with MIS-C at the pediatrics department of the study center from August 2021 to December 2021. Data related to age, sex, body mass index, vital findings, laboratory data, clinical symptoms, ultrasonography, and echocardiography findings were acquired from hospital records. Cardiac markers were compared with respect to clinical symptoms and imaging. Results Fever (91.2%), rash (50%), and abdominal pain (44.1%) were the most observed symptoms. Echocardiography visualized mild mitral regurgitation in 12 patients (35.3%), pericardial effusion in 9 patients (26.5%), and mild coronary dilatation in 9 patients (26.5%). All patients received corticosteroids, whereas acetylsalicylic acid was prescribed in 29 patients (85.3%) and intravenous immunoglobulins were administered in 21 patients (61.8%). Serum probrain natriuretic peptide concentrations were significantly higher in MIS-C patients with rash than those without rash (9,592.2 ± 7,764.5 vs. 1,501.2 ± 1,385.4 pg/mL, p = 0.021). Serum troponin T concentrations were significantly higher in MIS-C patients with ileitis than those without ileitis (0.026 ± 0.024 vs. 0.008 ± 0.003 µg/L, p = 0.013). Serum troponin T concentrations were also significantly higher in MIS-C patients with pericardial effusion than those without pericardial effusion (0.022 ± 0.020 vs. 0.008 ± 0.007 µg/L, p = 0.036). Conclusion The presence of rash and sonographic visualization of ileitis might act as signs for cardiac involvement in children exposed to COVID-19. To assess the cardiac involvement in MIS-C patients, cardiac enzymes should be measured and echocardiography examination should be performed.
No takes yet. Share an insight, caveat, or question.
Pektaş et al. (2023) conducted an observational in Multisystem inflammatory syndrome (MIS-C) associated with COVID-19 (n=34). Rash vs. No rash was evaluated on Serum probrain natriuretic peptide concentrations (p=0.021). In children with MIS-C, the presence of rash was associated with higher serum probrain natriuretic peptide concentrations compared to those without rash.
Synapse has enriched 10 related papers. Consider them for comparative context: