Key result
Maternal obesity is not associated with increased risk or severity of isolated congenital heart defects.
Why the study?
The association between maternal obesity and isolated congenital heart defects in offspring was uncertain.
Does maternal obesity increase the incidence and severity of isolated congenital heart defects in offspring?
Population
428 women divided into normal weight (n=141), obese (n=228), and morbidly obese (n=59)
Comparison
Obese and morbidly obese women vs normal weight women
Design
Retrospective observational study
Authors
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Null association in registry data; should not change preconception counseling and leaves open causal questions for prospective study.
Observational (n=428)
Does maternal obesity increase the incidence and severity of isolated congenital heart defects in offspring?
This retrospective study found no significant association between maternal obesity and the incidence or severity of isolated congenital heart defects in offspring.
Khalil et al. (2008) conducted an observational in Isolated congenital heart defects (n=428). Maternal obesity vs. Normal weight was evaluated on Incidence and severity of isolated CHDs. Maternal obesity was not significantly associated with the incidence, type, or severity of isolated congenital heart defects in offspring compared to normal maternal weight.
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