We developed a novel method for the synthesis of 2-alkenyl primary benzamides. This method is a unique cobalt-catalyzed tandem nitrile hydration/regioselective alkyne hydroarylation employing 2-cyano-substituted phenylboronic acids and 1-aryl-2-trimethylsilylacetylenes. A prominent feature of this reaction is its excellent chemoselectivity, regioselectivity, and stereoselectivity.
No takes yet. Share an insight, caveat, or question.
Ueda et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: