Substantial evidence indicates that long-term exposure to fine particulate matter from multiple combustion sources contributes to cardiovascular disease. An integrated exposure-response approach uses evidence from exposures to air pollution, second hand smoke, and active cigarette smoking to explore mortality exposure-risk relationships. Although there are limitations, this approach provides a useful framework to evaluate consistency and coherency of the evidence and to estimate burden of disease from air pollution.
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Pope et al. (2018) studied this question.
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