Synthesis of 3‐aminorhodanine derivatives as aldose reductase inhibitors

A number of 5‐condensated 3‐acylaminorhodanines 3 was prepared as potential inhibitors of the aldose reductase by acylation of the amino group of 3‐aminorhodanine 1 and subsequent condensation of the 5‐methylene function with appropriate aldehydes. Some of these compounds displayed interesting activity.