Key result
Ferulic acid administration (200 mg/kg) significantly reduced cisplatin-induced elevations in serum creatinine and urea in tumor-bearing mice, while enhancing the anticancer efficacy of cisplatin.
Why the study?
Does Ferulic acid ameliorate Cisplatin-induced nephrotoxicity and oxidative stress in tumor bearing mice?
Does Ferulic acid ameliorate Cisplatin-induced nephrotoxicity and oxidative stress in tumor bearing mice?
Absolute Event Rate: 1.5% vs 2.5%
p-value: p=<0.001
Ferulic acid demonstrates a protective effect against cisplatin-induced nephrotoxicity while enhancing its chemotherapeutic efficacy in a preclinical mouse model.
Should not yet alter cisplatin use; leaves open human translation of ferulic acid as adjunct.
Cisplatin (Cis) is one of the most widely used cytotoxic therapeutic agents for the treatment of cancer. Overdose of the drug resulted in various side effects of genotoxicity and nephrotoxicity. The toxicity of the drug has been attributed to the generation of oxidative free radicals. The current study aims to explore the effect of Ferulic acid (FA) in ameliorating Cis-induced renal toxicity in tumor bearing Swiss albino mice. Nephrotoxicity was induced in tumor bearing mice by a single dose of Cis (12mg/kg, i.p). Post administration of FA was carried out (100 mg/kg p.o and 200 mg/kg p.o) one hour after Cis administration. Toxicity was measured by analyzing the amount of serum urea, creatinine, and antioxidant status of renal and tumor tissues. Treatment of cisplatin-administered tumor animals with the FA could prevent the drug-induced oxidative damage as evidenced by the decreased levels of lipid peroxidation and enhanced activities of the antioxidants in the renal tissues. The treatment also protected the renal tissues from the toxic effects of Cis by reducing the levels of serum urea and creatinine. FA protected the renal tissues, whereas it enhanced the anticancer efficacy of Cis in tumor tissues. The histopathological observations support that ferulic acid has a protective effect against Cisplatin-induced nephrotoxicity and can be used to improve the chemotherapeutic index of Cisplatin for cancer treatment.
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Divakaran et al. (2021) studied Cisplatin-induced nephrotoxicity in tumor-bearing mice (n=20). Ferulic acid vs. Cisplatin alone (12 mg/kg i.p.) was evaluated on Serum creatinine (mg/dL) (p=<0.001). Ferulic acid administration (200 mg/kg) significantly reduced cisplatin-induced elevations in serum creatinine and urea in tumor-bearing mice, while enhancing the anticancer efficacy of cisplatin.
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