Key result
Irritable bowel syndrome was not associated with significant differences in the resting-state global functional organization of the pain matrix and default mode network compared to healthy controls.
Why the study?
Do resting-state functional properties of the pain matrix and default mode network differ between IBS patients and healthy controls?
Cross-Sectional (n=150)
Yes
Do resting-state functional properties of the pain matrix and default mode network differ between IBS patients and healthy controls?
p-value: p=>0.2
Resting-state functional connectivity of the pain matrix and default mode network does not significantly differ between IBS patients and healthy controls, suggesting that network responses to visceral stimulation rather than resting organization may be primarily disturbed in IBS.
No resting-state graph differences detected in IBS; leaves open whether task-evoked or dynamic connectivity drives symptoms.
Irritable bowel syndrome (IBS) is a functional disorder of brain-gut interactions. Differential brain responses to rectal distention between IBS and healthy controls (HCs) have been demonstrated, particularly in the pain matrix and the default mode network. This study aims to compare resting-state functional properties of these networks between IBS patients and HCs using graph analysis in two independent cohorts. We used a weighted graph analysis of the adjacency matrix based on partial correlations between time series in the different regions in each subject to determine subject specific graph measures. These graph measures were normalized by values obtained in equivalent random networks. We did not find any significant differences between IBS patients and controls in global normalized graph measures, hubs, or modularity structure of the pain matrix and the DMN in any of our two independent cohorts. Furthermore, we did not find consistent associations between these global network measures and IBS symptom severity or GI-specific anxiety but we found a significant difference in the relationship between measures of psychological distress (anxiety and/or depressive symptoms) and normalized characteristic path length. The responses of these networks to visceral stimulation rather than their organisation at rest may be primarily disturbed in IBS.
No takes yet. Share an insight, caveat, or question.
Kano et al. (2020) conducted a cross-sectional in Irritable bowel syndrome (n=150). Irritable bowel syndrome vs. Healthy controls was evaluated on Global normalized graph measures (clustering coefficient, efficiency, betweenness centrality, characteristic path length) of the pain matrix and default mode network (p=>0.2). Irritable bowel syndrome was not associated with significant differences in the resting-state global functional organization of the pain matrix and default mode network compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: