Key result
Preoperative aspirin discontinuation is linked to lower chest tube drainage after OPCABG.
Why the study?
The impact of discontinuing aspirin and clopidogrel before off-pump coronary artery bypass grafting on postoperative bleeding and transfusion requirements was unclear.
Does discontinuation of aspirin and clopidogrel before surgery reduce postoperative bleeding and transfusion requirement in OPCABG patients?
Observational
Does discontinuation of aspirin and clopidogrel before surgery reduce postoperative bleeding and transfusion requirement in OPCABG patients?
Answers are grounded in this paper and cite their sources.
Discontinuing aspirin before OPCABG may reduce early postoperative bleeding, and discontinuing clopidogrel for ≤5 days may reduce perioperative arrhythmias without increasing bleeding risk compared to standard guideline protocols.
OPCABG patients who discontinued aspirin before surgery had lower postoperative 12 hours CTD volumes but similar blood products transfusion rate and CTD volumes beyond 12 hours postoperatively compared with patients adhering to the current guideline-recommended protocol. And for patients who discontinued clopidogrel for ≤5 days, postoperative CTD volumes and blood products transfusion requirement were similar but the incidence of perioperative arrhythmia was significantly lower compared with guideline-treated patients.
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Wang et al. (2019) conducted an observational in Off-pump coronary artery bypass grafting (OPCABG). Discontinuation of aspirin and clopidogrel before surgery vs. Adherence to current guideline-recommended protocol was evaluated on Postoperative 12 hours chest tube drainage (CTD) volumes and blood products transfusion rate. Discontinuing aspirin before OPCABG lowered 12-hour chest tube drainage volumes, while discontinuing clopidogrel for ≤5 days reduced perioperative arrhythmia compared to guideline-treated patients.
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