Key result
Cefoperazone triggers life-threatening gastrointestinal bleeding from reversible hypoprothrombinemia in renal failure.
Why the study?
Coagulopathy and hemorrhage as complications of cefoperazone therapy are not widely recognized and may increase with greater drug use.
Case Report (n=1)
Cefoperazone therapy can be associated with life-threatening coagulopathy and hemorrhage, which is reversible with vitamin K and drug discontinuation.
Alerts clinicians to hypoprothrombinemia risk with cefoperazone; case report leaves open true incidence with wider use.
We have reported life-threatening gastrointestinal hemorrhage with hypoprothrombinemia in a patient treated with cefoperazone for a urinary tract infection. The coagulation abnormality was rapidly corrected with administration of vitamin K and discontinuation of the antibiotic. This complication of cefoperazone therapy is not widely recognized and may be seen more frequently with increased use of the drug.
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Shenkenberg et al. (1985) conducted a case report in Urinary tract infection and renal failure (n=1). Cefoperazone was evaluated on Gastrointestinal hemorrhage with hypoprothrombinemia. Cefoperazone therapy in a patient with renal failure caused life-threatening gastrointestinal hemorrhage and hypoprothrombinemia, which corrected after drug discontinuation and vitamin K administration.
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