Effects of injecting levocarnitine on weight coefficients and pathological picture of rats

This is the authors' abstract. We don't add key points for this paper.

L-carnitine is an essential amino acid (a building block of protein) required for fat and energy metabolism, and a nutrient that promotes normal functioning of the heart and skeletal muscles. Experimental and clinical results indicate the feasibility of using L-carnitine preparations in veterinary practice. There is no registered form of Levocarnitine injectables for use in animals of different species in the Russian Federation. The aim of our study was to establish the effect of injectable L-carnitine on the internal organs of laboratory animals. When studying subchronic toxicity, the animals were divided into 3 groups of 10 animals each. The drug was administered intramuscularly daily for 42 days, to the first group at a dose of 0.08 mg / kg, to the second group 0.04 mg / kg, the third group was a control. Slaughter of 50% of the rats for the purpose of collecting biological material was carried out the next day after the end of the drug administration (43rd day of the experiment), in the remaining animals 10 days after the end of the injection (53rd day). Pathological examination of the corpses of unproductive animals was carried out in accordance with GOST R 57547-2017. The Mann-Whitney statistical criterion was used to process the data. During the pathological examination (autopsy) of the corpses of laboratory animals on days 43 and 53 of the experiment, the pathological picture did not change, but isolated changes were found in the heart and liver of rats in the experimental groups. The absence of statistically significant changes in the weight coefficients may indicate the stability of this indicator when using levocarnitine in the studied dosages and administration times.