Synthesis and antimicrobial activity of some new macrocyclic bis-sulfonamide and disulfides

Synthesis and antimicrobial evaluation of some typical macrocyclic crown ethers including amide, sulfonamide, and disulfide moieties are reported. Novel macrocyclic bis -sulfonamide, amide, and disulfides are prepared by reacting the bis -chlorides and diamines by fast addition method. The antimicrobial activities of the synthesized compounds are measured. Bis -sulfonamide and disulfide crown ethers showed antibacterial activities against most strains tested.