Key result
PAD linked to ~86% higher risk of incident disability, independent of baseline physical function.
Why the study?
The predictive value of peripheral arterial disease for incident disability and the extent to which baseline physical function explains this relationship were unclear.
Does peripheral arterial disease predict incident disability in elderly Japanese adults?
Cohort (n=783)
No
Does peripheral arterial disease predict incident disability in elderly Japanese adults?
Peripheral arterial disease is a significant predictor of incident disability in elderly individuals, even among those with high baseline physical function.
Answers are grounded in this paper and cite their sources.
PAD may flag higher disability risk in older adults beyond physical function; leaves open whether screening or interventions improve outcomes.
AIM: The aim of this study was to investigate whether peripheral arterial disease (PAD) is predictive of disability and whether the relationship between PAD and disability can be fully explained by baseline physical functions. METHODS: We followed for five years 783 Japanese aged 70 years or older without a disability at baseline in 2003. We defined participants certificed as requiring long-term care as having incident disability. The hazard ratio (HR) and 95% confidence interval (95% CI) for incident disability were calculated using the Cox proportional hazards model. RESULTS: After adjusting for possible confounders other than physical function, the HR of incident disability among participants with PAD was 1.86 (95%CI: 1.06 to 3.26).Although the risk was attenuated (HR=1.63, 95%CI: 0.92 to 2.86) after adding baseline physical function as a covariate, the HR was still high. Furthermore, the relation was not statistically significant, but the group with higher physical function and PAD also had a higher HR of incident disability than those who had higher physical function without PAD. CONCLUSION: PAD is an important predictor of disability even if the level of baseline physical function is high.
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Nitta et al. (2010) conducted a cohort in Peripheral Arterial Disease (n=783). Peripheral arterial disease (PAD) vs. Without PAD was evaluated on Incident disability (assessed by long-term care insurance certification) (HR 1.86, 95% CI 1.06-3.26). Peripheral arterial disease was associated with an 86% increased risk of incident disability (HR 1.86) compared to those without PAD, independent of baseline physical function.
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